Materials, Design & Engineering for Sensor Manufacturing

Next-generation smart sensors for wearables, implantables, digital health, environmental, logistics, security, home automation and industrial applications have helped to propel this market to enormous growth over the last 10 years. This track will focus on how optimizing materials, design and engineering for efficient manufacturing is critical to meet the growing demand for sensors for all applications. This conference track will examine these emerging sensor markets and will showcase the latest technological advancements in research and development for manufacturing.

Tuesday, December 10

7:30 am Registration and Morning Coffee

Plenary Session

8:20 Chairperson's Remarks

Stacey Standridge, PhD, Deputy Director, National Nanotechnology Coordination Office

8:30 Wear, implant and analyze: sensors and the future of chronic care

Rafael Carbunaru, PhD, Vice President R&D, Boston Scientific

As rates of chronic disease climb, so do opportunities for wearable and implantable solutions to help manage them. Core technology and sensor improvements; integration into healthcare systems; robust security; and personalized experience could all speed adoption. This talk will address current market and opportunities, and include examples of using wearables, sensors and analytics in a proof-of-concept clinical study and life-saving AI for chronic disease applications.

9:00 Regulatory Considerations during Mobile Medical App Development for Commercial and Clinical Trial Use

 Mike Benecky, Senior Director, Global Regulatory Affairs in Precision and Digital Medicine, GlaxoSmithKline

Mobile medical apps are defined as medical devices from their intended use. Mobile medical app regulation is health risk-based to balance patient safety and barriers to technological innovation. Medical device patient risk analysis is a critical prerequisite prior to sensor/app inclusion within a clinical trial. Key components of quality management systems for mobile medical apps include: software requirements/specifications, user acceptance testing, software postmarket surveillance, software version control and medical device adverse event reporting.             

9:30 Nanotechnology, MEMS, Microfluidics for Health 4.0 Hypermobility

Anita Rogacs, PhD, Head of Life Sciences Strategy and R&D, Hewlett Packard Labs

New imperatives of healthcare are focusing on prevention, personalization of diagnostics and treatment, and democratization, including access to everyone, anywhere, anytime at a low cost. The technology convergence in medicine is enabled by the powerful
combination of microelectronics, microfluidics, advanced (bio)-chemistry, distributed network, and data analytics.



10:00 Networking Coffee Break

10:30 Roundtable Discussions

Roundtable discussions are informal, moderated discussions with brainstorming and interactive problem solving, allowing participants from diverse backgrounds to exchange ideas and experiences and develop future collaborations around a focused topic. Each topic is led by a moderator who ensures focused conversation around the key issues of that topic. Attendees choose to join a specific group.

TABLE 1: How Biosensors Can Address Global Health Challenges

Lisa Diamond

Table 2: Power Solutions for Miniaturized Implants

Robert Rubino, Senior Director, Research and Development, Integer

Table 3: Mixed-Signal Application Specific Integrated Circuits (ASICs): Advantages, Challenges, Justification, and Strategies

Andrew Kelly, BSEE, Director of Applications Engineering, Semiconductor Division, Cirtec Medical

Table 4: Overcoming the Challenges to Bringing Medical Devices to The Market

David DiPaola, Managing Director, DiPaola Consulting

Table 5: Advanced Materials

Stacey Standridge, PhD, Deputy Director, National Nanotechnology Coordination Office

Table 6: Sensors for Collaborative or Autonomous Systems: Challenges and Considerations

Tom Calef, CTO, Activ Surgical

  • What industries are exploring such systems and what can be learned from them?
  • What sensor types and circuit architectures are well-suited for such systems?
  • What factors should be considered when deciding to either work with a sensor supplier or develop in-house?
  • What are current user-acceptance or regulatory/compliance challenges and successful case studies for overcoming them?
  • How is data being collected, stored, and used in today’s learning models?  What are the best practices for specific industries?
  • What is required for these systems to take the next “big leap” into Level 3 autonomous behavior or beyond?

11:15 Transition to Sessions

Market and the Path to Commercialization

11:25 Chairperson's Remarks

Steve Lerner, CEO, Alpha Szenszor

11:30 BARDA’s New Division of Research Innovation for the Development of Next-Generation Wearables

 Justin Yang, Program Analyst, Biomedical Advanced R&D Authority, US Department of Health & Human Services

This presentation will provide an overview of the vision of the Biomedical Advanced Research & Development Authority's new Division of Research, Innovation, and Ventures in the Department of Health and Human Services and their new focus on wearable technologies. We are funding multiple projects seeking to improve healthcare and health outcomes by enabling Americans to monitor their own health. We seek wearable technologies to enable a notification of impending disease before symptoms arise.

 

Advanced Sensor Materials & Engineering

12:00 pm Miniaturization Technologies for Implantable Devices

Robert Rubino, Senior Director, Research and Development, Integer

In order to make future implantable medical devices as minimally invasive and cost-effective as possible, devices will need to become smaller and easier to implant. This will require the development of alternative assembly technologies and materials. Reduction in the size of the power source, while still retaining the high level of reliability required, will be one critical element to reduce device size. New concepts to allow for miniature scale assembly of hermetic, biocompatible coin cells and thin film cells have been developed by leveraging traditional glass-to-metal and ceramic-to-metal seal technologies. Ceramic  device enclosures, which allow for more efficient energy transfer to the device from external power sources due to reduced eddy currents, have been developed to minimize recharge time or eliminate the need for a power source completely. In addition, biocompatible, hermetic conductive vias through ceramic substrates enable further size reduction of device feedthroughs and can act as active electrodes for sensing or therapy. Combined, these technologies can be used to produce sensing and stimulating implants that provide enhanced convenience for patients and physicians.

12:30 Enjoy Lunch on Your Own

Advanced Sensor Materials and Engineering

1:55 Chairperson's Remarks

Roger Grace, President, Roger Grace Associates

2:00 Radio Ranging with Ultra-High Resolution with Passive Markers

 Edwin Kan, Prof, Electrical & Computer Engineering, Cornell Univ

Accurate locating of specific points in an indoor setting is critical for applications, including robotic feedback control and non-intrusive structural integrity monitoring. Current optical and ultrasound approaches often suffer from insufficient accuracy, obstruction by other objects, and ambiguous identification. Alternatively, conventional radar-like radio frequency (RF) methods can suffer from problems such as multipath ambiguity, small time of flight, and limited item recognition. Attachment of a passive RF identification (RFID) tag can provide a unique marker by modulating the backscattering signal, but current systems struggle with large interference and noise, and thus have poor ranging accuracy. Here we show that a 1 GHz harmonic RFID system can provide a ranging resolution of less than 50 microns in air and less than 5 microns in water with a sampling rate of greater than 1 kHz. The fundamental limits on ranging precision in our system are traced to the phase noise of the RF source and the aperture jitter of the data converter. Due to the low signal loss of the RF band we choose, the small passive tag to be precisely tracked can be embedded in underwater objects as well as within building structures.


2:30 Low Power, Highly Scaled IoT Gas Sensors Using Carbon Nanotubes

Steve Lerner, CEO, Alpha Szenszor Inc

In the world of gas sensors that currently contend for Edge-based detection, incumbent technologies carry significant limitations with respect to integration, cost and power consumption. Sensor power consumption is a fundamental constraint for all portable sensing devices, particularly as the vision of energy harvesting and ubiquitous sensing at the Edge materialize. More recently, Carbon Nanotube sensors have evolved to being one of the most cost-effective options with greater packing density, higher sensitivity and selectivity, than most gas sensors, while consuming up to 3 orders of magnitude less power. This talk will discuss the inherent advantages of ultra-low power gas sensors and some of the applications that are being enabled as a result. From medical diagnostics to fitness monitors to environmental applications analyzing the quality of air, soil, water and food. CNT sensors are positioned to revolutionize our automated sense of smell and taste.

3:00 The Integration of Flexible Tactile Sensors into Biomedical and Consumer Products

 Robert M. Podoloff, MSME, CTO, Tekscan, Inc.

This talk will focus on the information that flexible tactile sensors can provide and the process for integrating them into consumer products. Several applications examples ranging from prevention of occlusion in insulin delivery lines to the measurement of dynamic automobile tire footprints will be presented along with a live demonstration of the technology.

3:30 Refreshment Break in the Exhibit Hall with Poster Viewing

4:00 Tutorials (See page 3 for details.)

6:00 Welcome Reception in the Exhibit Hall with Poster Viewing

7:00 End of Day

Wednesday, December 11

8:00 am Registration and Morning Coffee

Plenary Session

8:20 Chairperson's Remarks

Robert Rubino, Senior Director, Research and Development, Integer

8:30 Dexcom's Continuous Glucose Monitoring (CGM) Technology and Its Impact on Diabetes Management, Artificial Pancreas, & Digital Health Systems

Peter Simpson, Vice President of Sensor R&D and Advanced Technology, Dexcom

Recent advances in continuous glucose monitoring (CGM) technology have significantly increased its usability and impact on diabetes management.  CGM's are now widely reimbursed and are rapidly becoming the standard of care for all people on intensive insulin therapy.


This presentation will provide an overview of Dexcom's CGM sensor technology, its use in digital health and artificial pancreas systems and a preview of our future products.


9:00 Objective Measures for Clinical Assessment and Precise Understanding of Disease Progression

 Christopher Hartshorn, PhD, Program Director, Cancer Treatment & Diagnosis, National Institutes of Health; National Cancer Institute

Cancer patients disconnected from resource intensive cancer centers face challenges beyond simply the disease they are dealing with.  These patient populations include both ones in rural communities as well as populations whom have access hindered via disability, transportation or time. This limited access to the care system also presents a problem for clinical teams involved in caring for and assessing patient status and therapeutic response. Connected health solutions (i.e., autonomous or interactive devices and mobile apps that deliver health data to the user and / or clinical team) have been increasing in use, gradually over the last decade, yet very few have reached the maturity needed for cancer-specific, clinically relevant applications.  Moreover, the next generation of these tools goes beyond contextual and vital sign measurement (e.g., physical sensors) into passive wireless measures for systemic molecular characterization (e.g., continual biomolecular measurements from interstitial fluid, sweat) and assessment of local biology (e.g., implantable biosensors). Ultimately, these passive sensing platforms of ‘digital biomarkers’ will afford clinicians 1) more objective metrics of response to therapeutics; 2) control and auto-reporting of symptoms and their fluctuations; 3) monitoring of side-effects of experimental or standard of care therapies; and 4) more ecologically valid clinical endpoints, all decreasing assessment burden via increased continuity of physiological measurement sampling and patient context, outside of the standard clinical visit.  This talk will look at various efforts across the National Institutes of Health attempting to enable more objective measures for out-of-clinic patient-specific assessment and longitudinal understanding of disease progression in large cohorts.

9:30 Wearable Electrochemical Sensors – Recent Advances

Joseph Wang, Distinguished Professor & Chair, Nanoengineering, University of California, San Diego

This presentation will discuss recent developments in the field of wearable electrochemical sensors integrated directly on the epidermis or within the mouth for various non-invasive biomedical monitoring applications. Particular attention will be given to non-invasive monitoring of metabolites and electrolytes using flexible amperometric and potentiometric sensors, respectively, along with related materials, energy and integration considerations. The preparation and characterization of such wearable electrochemical sensors will be described, along with their current status and future prospects, and challenges. 

 

10:00 Coffee Break in the Exhibit Hall with Poster Viewing

10:30 Roundtable Discussions

Roundtable discussions are informal, moderated discussions with brainstorming and interactive problem solving, allowing participants from diverse backgrounds to exchange ideas and experiences and develop future collaborations around a focused topic. Each topic is led by a moderator who ensures focused conversation around the key issues of that topic. Attendees choose to join a specific group.

Table 1: Miniaturization for Chemical and Biological Detection

Cory Bernhards, PhD, Research Microbiologist, CBR, Defense Threat Reduction Agency

Table 2: Best Practices for AI, IoT, etc

Aminat Adebiyi, PhD, Research Staff Member,Biomedical IoT and Applied Analytics, IBM

Table 3: The Small Business Innovation Research (SBIR) program and Small Business Technology Transfer (STTR)

Juan Figueroa, PhD, Entrepreneurship Advisor and Associated Researcher, Puerto Rico Science and Technology Trust

Table 4: Non-Invasive Physiological Monitoring Beyond Activity, PPG, RR and ECG - Adding More Medically Relevant Vital Signs

Ashish V. Pattekar, Principal Scientist, PARC, a Xerox Company

Table 5: Overcoming the Pitfalls to Sensor Commercialization

Roger H Grace, President, Roger Grace Assoc

11:15 pm Transition to Sessions

Enabling Sensor Commercialization through Collaborative Initiatives

11:25 Chairperson's Remarks

Robert Rubino, Senior Director, Research and Development, Integer

11:30 The NNI Sensors Signature Initiative: Facilitating Collaboration to Advance Nanosensor Development and Commercialization

 Stacey Standridge, PhD, Deputy Director, National Nanotechnology Coordination Office

The NNI’s Nanotechnology for Sensors and Sensors for Nanotechnology Signature Initiative (Sensors NSI) coordinates efforts and stimulates existing and emerging projects across federal agencies to explore the use of nanotechnology for the development and commercialization of sensors. This presentation will provide an update regarding current and planned activities of the Sensors NSI, with specific focus on needs, funding opportunities, and recent activities related to wearable and implantable sensors. The NNI is a U.S. Government research and development initiative involving 20 departments and independent agencies working together toward the shared vision of “a future in which the ability to understand and control matter at the nanoscale leads to a revolution in technology and industry that benefits society.

 

12:00 ANSI, the Value of Its Public-Private Partnership

Michelle Deane, Director, Standards Facilitation, Standards Facilitation, American Natl Standards Institute

ANSI enhances both the global competitiveness of U.S. business and the U.S. quality of life by promoting and facilitating voluntary consensus standards and conformity assessment systems, and safeguarding their integrity. One of the great strengths of the U.S. approach to standards and conformance is its “public-private partnership.” This presentation will provide an overview of this partnership, the U.S. standards process and how the Institute bridges the gap between industry and government and enables information exchange and access among standards developing organizations and public-sector leaders, agencies, and legislators.

 

12:30 Enjoy Lunch on Your Own

Sensor Design and Engineering for Manufacturing

1:55 Chairperson's Remarks

Stacey Standridge, PhD, Deputy Director, National Nanotechnology Coordination Office

2:00 Sputtered Metal Oxide N-P Heterojunctions for Sub-PPM Volatile Organic Compound Sensing

 Andrea Fasoli, PhD, Senior Sensor Engineer, RSM, IBM Almaden Research Center

We present the fabrication and characterization of sputtered SnO2/NiO n-p heterojunctions thin films and their response to Volatile Organic Compounds (VOCs) at sub-ppm concentrations. In optimal processing conditions, the response of the films to VOCs can be greatly increased and its dependence on temperature, typically described in the context of a Diffusion-Reaction model, altered. In addition, we show that p-type NiO layers of given thickness can trigger a reversal in the response pattern of ultra-thin n-type SnO2 underlayers.

2:30 The role of software in MEMS sensors: the silent stars of today’s and future applications

Francois Beauchaud, Principal Engineer, Business Development, Bosch Sensortec

MEMS sensors have become the heart of many consumer electronic devices like smartphones and wearables. Their use in adjacent markets like the industrial market has not yet reached its full potential as each application has different requirements in terms of accuracy, power consumption, stability, memory and latency, resulting in varying needs for fused sensor data. Applications like predictive maintenance require constant adaptation and a scalable solution.
In his talk, Francois Beauchaud, Principal Engineer Business Development at Bosch Sensortec, will introduce solutions at different complexity levels of sensor related software such as fusion, user features and deployment of modern edge AI techniques, to provide a stage to the silent stars within our daily devices.

3:00 Enabling Permanently-Powered Deeply Embedded Sensor Systems

 Mark Buccini, Dir Advanced Product Platforms, Advanced Product Platforms, Texas Instruments Inc

 

This presentation describes the architecture choices and design techniques that have been proven to enable deeply embedded sensor systems to operate for a lifetime from a single non-replaceable or rechargeable primary battery source.  The solution discussed is usable as a template to implement permanently-powered fitness, monitoring, portable health care and wearable devices.  A practical step-by-step series of examples build a complete ultra-low power cost-sensitive microcontroller-based embedded system.  E xactly where at a system level power is consumed and how to minimize is it the focus of the presentation. 

 

3:30 Refreshment Break in the Exhibit Hall with Poster Viewing

4:00 Tutorials (See page 3 for details.)

6:00 End of Day


For more details on the meeting please contact the conference organizing committee:

Craig Wohlers
Executive Director, Conferences
Cambridge Innovation Institute
Phone: (+1) 781-972-6260
Email: cwohlers@cambridgeinnovationinstitute.com

For sponsorship and exhibit sales information, please contact:

Jon Stroup
Senior Manager, Business Development
Cambridge Innovation Institute
Phone: (+1) 781-972-5483
Email: jstroup@cambridgeinnovationinstitute.com

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