TRACK 1: BIOSENSORS - Technological Advances and Commercial Applications in Biosensing
The global market for biosensors is expected to reach over $25 billion by 2020. With biosensor applications in such areas as healthcare, environmental, industrial, security and defense, this market is expected to achieve exponential growth over the coming
years. This conference track will focus on the latest in commercialization and technological advances in biosensors and will include such areas as:
- Bioelectronics
- DNA Chips, Nucleic Acid Sensors and Aptasensors
- Enzyme-Based Biosensors
- Immunosensors
- Lab-on-a-Chip
- Microfluidics
- Nano-Enabled Sensors
- BioMEMS
- Natural & Synthetic Receptors
| - Organism- and Whole Cell-Based Biosensors
- Proteomics, Single-Cell Analysis and Cancer-Cell Detection
- Implantable Sensors
- Scalable Sensor Manufacturing and Microfabrication
- Regulatory Considerations
- Market Analysis and Forecasting
- Wearables
- Wireless Sensor Networks
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Tuesday, November 10
7:30 am Conference Registration and Morning Coffee
8:55 Chairperson’s Opening Remarks
Kalle Levon, Ph.D., Research Professor, Chemical and Biomolecular Engineering Department, New York University
PLENARY KEYNOTE PRESENTATIONS
9:00 High-Rate Nanoscale Printing for Sensors, Energy and Materials Applications
Ahmed Busnaina, Ph.D., William Lincoln
Smith Professor, Distinguished University Professor & Director, The NSF Nanoscale Science and Engineering Center for High-Rate Nanomanufacturing, Northeastern University
The NSF Center for High-Rate Nanomanufacturing (CHN) has developed a new nanoscale printing process that can use a variety of nanomaterials and can print onto a variety of substrates with nanoscale resolution match the present state of the art silicon
electronics circuit line width. Last year, the center developed and built a fully-automated robotic cluster tool system that prints at the nanoscale to make products that fully take advantage of the superior properties of nanomaterials. Because
of its relative simplicity, the fully automated Nanoscale Offset Printing System (NanoOPS) is expected to eliminate some of the high cost entry barriers to the fabrication of nanoscale devices for sensors, electronics, energy, medical, and functional
materials applications.
9:35 Mobile Experience Application Platforms for Internet of Things/Everything (IOT/IOE)
Peter Mason, Director, Applications Platform
Group, Cisco
Cisco estimates that 50 billion devices and object will be connected to the internet by 2020. Yet today, more than 99% of things in the physical world remain unconnected. This presentation will highlight how the Internet of Things and Big Data fit
into IoE, and enable business outcomes through (1) new business models, products, and services; (2) increased enterprise speed and agility; (3) improved decision making; and (4) an unprecedented customer experience. They will hear examples of
how Cisco and our customers are taking advantage of the data and information being generated by lighting up dark assets. Most importantly, they will gain valuable insights into the business and technology imperatives for the Internet of Everything.
10:10 Using Invention, Innovation and It's Resulting IP to Becoming Valuable to Your Value Chain as You Develop Sensors
John Cronin, Managing Director & Chairman, ipCapital Group
This presentation will describe case studies of creating large value through the use of focusing in invention, innovation and the resulting IP by virtualizing the future products. As we evaluate these case studies, it will become clear that focusing on
creating larger value is all about the systematic techniques and processes for invention, use of experts, use of market data and use of patent literature directions. The key takeaways will be to provide a unique insight for the sensor, biosensor and
power device organizations to see a brighter future for obtaining much higher value within the value chain.
10:40 Coffee Break with Poster Viewing
11:25 Chairperson’s Remarks
Kalle Levon, Ph.D., Research Professor, Chemical and Biomolecular Engineering Department, New York University
11:30 Tailored Interfaces for Photonic and Electrochemical Biosensing
Steve Semancik, Ph.D., Physicist and Project Leader, Biomolecular Measurement Division, National Institute of Standards and Technology (NIST)
Capabilities and performance characteristics for bioanalytical sensors are inherently connected to the properties of the material interfaces incorporated, for example, in photonic and electrochemical devices. This presentation will describe processing
methods for nanostructured materials that enable near-surface signal enhancement and bimodal sensing measurements. The utility of localized temperature control at interfaces will also be discussed for electrochemical monitoring of biochemical interactions.
12:00 pm Lenseless Microscopic Imaging for Comprehensive Monitoring of Cortical Neural Activity in Living Mammals
David G. Stork, Ph.D., Research Director, Rambus Labs
A powerful technique in optogenetics is to insert special genes into neurons such that they fluoresce when momentarily active. Optical microscopes trained on exposed cortex in laboratory animals can then monitor the neural activity in real time. Because
the field of view of such microscopes is small (0.01 mm2), only a small number of neurons can be monitored simultaneously in this way. A new approach is to use lensless microscopic imaging to vastly increase the area of the cortex that can be
so monitored. This talk will describe simulations of cortical monitoring by such sensors, an overview of experimental plans, the scientific questions such monitoring can address, and possible therapeutic opportunities for brain-machine interfaces.
12:30 Networking Lunch
1:55 Chairperson’s Remarks
Edwin Kan, Ph.D., Professor, School of Electrical and Computer Engineering, Cornell University
2:00 Complementary Metal-Oxide Semiconductor
(CMOS) Biosensors
Edwin Kan, Ph.D., Professor, School of Electrical and Computer Engineering, Cornell University
With mass production fast marching to 17nm CMOS technology and beyond, we are fast approaching the information resolution of the biological systems such as DNA/RNA and cellular ion channels. The close proximity of CMOS sensing, amplification,
data conversion and transmission enables cost reduction and least noise injection. I will present two successful enzyme-free and readout-label-free sensing for applications of fast epidemic disease diagnosis and intercellular signaling monitoring
of enteric neurons. With the unparalleled resolution in space and time, high sensitivity and versatile integration, the CMOS biosensor platform is potential to bring forth the next-generation molecular interface to the electronic computer.
2:30 Biosensing with Ion Sensitive Floating Gate Field Effect Transistor Array
Kalle Levon, Ph.D., Research Professor, Chemical and Biomolecular Engineering Department, New York University
Enzyme-Linked ImmunoAssay (ELISA) tests is an optimal method to be used with the hybrid system of Ion Sensitive Floating Gate Field Effect Transistor Array and electrically conducting polymers (ECP). The enzymatic redox reaction affects conducting
polymer properties, which further can be read by the change in the threshold voltage of the transistor. We shall present how organic conductors can be used to functionalize ion sensitive floating gate field effect transistors (ISFGFETs)
designed to measure biological binding events. Our conductive polymer modified ISFGFET sensor arrays are a promising alternative to optical biosensors due to their signal amplification, high throughput and scalability advantages.
3:00 Personalized and Hand-Held Breath-Based Diagnostics
Perena Gouma, Ph.D., Professor, Materials Science and Engineering, Director, Center for Nanomaterials and Sensor Development, SUNY Stony Brook, NY
This talk will highlight the research and development efforts of my team towards the personalized diagnostic breathalyzer to be used for the detection and monitoring of diseases or metabolic malfunctions, both in humans and in livestock.
Based on the principle of selective chemosensing, nanostructured, gas-selective probes have been developed which detect disease-signaling biomarkers in a single exhale. These sensing probes, whether individually or in arrays, constitute
components of sensory systems that are inexpensive, handheld, wireless, and low-power. The pathway and timeline from lab-based prototyping to industrial scale manufacturing of this technology are also discussed here.
3:30 Refreshment Break with Poster Viewing
4:10 PLENARY PANEL DISCUSSION: Sensor Commercialization - Challenges and Opportunities
Moderator:
Lisa Friedersdorf, Deputy Director, National Nanotechnology Coordination Office, National Nanotechnology Initiative
Panelists:
Steve Semancik, Ph.D., Physicist and Project Leader, Biomolecular Measurement Division, National Institute of Standards and Technology (NIST)
Joshua Windmiller, Ph.D., CTO, Electrozyme, LLC
Len Sheynblat, Vice President,
Engineering, Qualcomm
This panel will focus on the identification and discussion of challenges that are faced by the sensor development community during the fabrication, integration, and commercialization of sensors. The National Nanotechnology Coordination
Office (NNCO) provides technical and administrative support to the Nanoscale Science, Engineering, and Technology (NSET) Subcommittee, serves as a central point of contact for Federal nanotechnology R&D activities, and provides
public outreach on behalf of the National Nanotechnology Initiative.
5:10 End of Day One
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Wednesday, November 11
8:30 am Conference Registration and Morning Coffee
8:55 Chairperson’s Opening Remarks
Perena Gouma, Ph.D., Professor, Materials Science and Engineering; Director, Center for Nanomaterials and Sensor Development, SUNY Stony Brook
PLENARY KEYNOTE PRESENTATIONS
9:00 Personalization in Sensor-Rich Environments
Martha G. Russell,
Executive Director, mediaX, Stanford University
The right message, at the right time, in the right place is increasingly an expectation of consumer and business information systems. As context awareness emerges as a differentiating factor for interactive applications, both embedded
and mobile sensors are evolving to contribute to this vision. Personal identity is a complex, dynamic construct. It is simultaneously individual and social, predictable and emergent, often culturally and situationally dependent.
New opportunities for personalization in sensor-rich environments include frontiers in human sciences, as well as in information technologies.
9:30 Nano-Enabled Biosensors: From Bench-to-Bedside
Christopher
M. Hartshorn, Ph.D., Program Manager, Office of Cancer Nanotechnology Research, National Cancer Institute
Nano-enabled biosensors (e.g. biosensors utilizing nanotechnology for recognition, transduction, or both) offer much potential with their inherent high surface-to-volume ratios, multi-functionality, and unique physical/chemical properties.
Regardless of what combination of recognition element/material/signal transduction mechanism eventually employed, an ideal biosensor must be able to effectively discriminate the analyte(s), detect low quantities, and have a broad
dynamic range. This talk will focus on several in vitro and in vivo nano-enabled diagnostic sensing platforms that are at multiple stages of the development and commercialization pathway. Exploration into their needs for successful
translation as well as future trends in their application to personalized medicine and cancer will be discussed.
10:00 Coffee Break with Poster Viewing
10:25 Chairperson’s Remarks
Perena Gouma, Ph.D., Professor, Materials Science and Engineering; Director, Center for Nanomaterials and Sensor Development, SUNY Stony Brook
10:30 Path to Commercialization through Regulatory Assessment of Safety & Effectiveness
Orlando Lopez, Ph.D., Biomedical Engineer, Lead Regulatory Reviewer, Office of Device Evaluation, FDA
11:00 Wearable Epidermal and Transdermal Biosensors: Understanding the Chemical Self
Joshua Windmiller, Ph.D., CTO & Founder, Biolinq Technologies, Inc.
This talk highlights the development of a novel class of minimally- and non-invasive electrochemical biosensors that facilitate the quantification of relevant metabolomic, electrolytic, hormonal, and neurochemical information in a continuous,
real-time fashion. Fabricated through manufacturing processes that are scalable, cost-effective, and have a minimum environmental footprint, these novel biosensing modalities seek to bridge the gap between analytical-grade instrumentation
typically found in the hospital laboratory and user requirements for unobtrusive, low-profile, skin-applied devices able to deliver timely, actionable information using existing wirelessly-enabled wearable and mobile platforms.
11:30 2D Semiconductor Crystals for Next-Generation Label-Free FET Biosensors
Kaustav Banerjee, Ph.D., Professor, Electrical and Computer Engineering, Director, Nanoelectronics Research Lab, University of California, Santa Barbara
2-dimensional (2D) layered crystals (such as graphene and molybdenum disulphide or MoS2) offer unique features such as atomically-thin body, high charge carrier mobility, and pristine surfaces, that allow large surface-to-volume ratio,
excellent electrostatics, and ease of heterostructure formation with low band-offsets for efficient band-to-band tunneling. This talk will provide an overview of such properties of 2D crystals and discuss how those features can
be uniquely exploited to build a revolutionary new class of ultra-sensitive and ultra low-power/low-cost field-effect-transistor (FET) based label-free biosensors.
12:00 pm Closing Remarks and End of Conference
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For more details on the meeting, please contact:
Craig Wohlers
General Manager
Knowledge Foundation
Phone: (+1) 781-972-6260
Email: cwohlers@knowledgefoundation.com
For partnering and sponsorship information, please contact:
Sherry Johnson
Business Development Manager
Knowledge Foundation
Phone: (+1) 781-972-1359
Email: sjohnson@healthtech.com